I take Prozac, Wellbutrin, Topimax, Clonazapam, Ambien, and Seroquel for medication resistant depression, PTSD, anxiety disorder, and agoraphobia. I used to run 5 miles every day and bike 27 miles with my kids a few days a week. I was on medication then but only Prozac and Xanax or Clonazepam. I am 5'8". I weighed 120 lbs. I had to have knee surgery on 6 different occasions and was forced to stop running. My depression got worse, my weight went up, even though I wasn't eating any differently. My highest weight was 215. I became a hermit. Along with the weight gain came more medication, more depression and isolation. It's a monster that has gotten out of control. I have a treadmill, exercise tapes etc. I was using them daily and got down to 170 lbs. Then I got sick and had to have some abdominal surgery. During the surgery there were complications. Now I am in pain most of the time. I'm back up to 200 lbs. I won't go anywhere. I can't get motivated enough to start exercising. I feel fat, old and useless. My antidepressants aren't helping me. The Seroquel makes me want to eat everything in sight so I don't take it unless I am having a really bad day and need to take a "day off and sleep". Should I be taking these awful antidepressants that I have been on for over 20 years or should I just get myself back into shape. I'm 50 years old now. I know I'll never look like I used to. I still have abdominal pain and knee pain. What do you say? Is it the exercise and the natural endorphin high that was keeping in normal or was it the Prozac. I often wonder if I were able to exercise religiously like I used to and slowly taper off the medication, if I would need to take all these anti-depressants. Any thoughts?